Differences in activity are noted throughout various subspecies; as a whole, the species is generally active during both daytime and nighttime, although the subspecies M. s. variegata are noted to be primarily nocturnal. 
The first description of M. spilota was by Lacépède (1804), who placed it in the genus Coluber as Coluber spilotus. The species has since been described by various authors as containing a number of subspecies and hybrids, these have also been known by various informal names. The attempted arrangement of taxa in this, and other, Australasian Pythonidae has produced numerous synonyms. The discreet and roaming habits of this species have produced a low number of recorded specimens, giving inadequate sample numbers to support descriptions of a taxon’s morphology. This is the case with proposed names which are sometimes cited, such as the Papuan Morelia spilota harrisoni (Hoser), despite being unaccepted or invalid. Common names are regional variants of carpet and diamond python or snake. [^2
The head is triangular with a conspicuous row of thermoreceptive labial pits.
The coloring of M. spilota is highly variable, ranging from olive to black with white or cream and gold markings. The patterning may be roughly diamond-shaped or have intricate markings made up of light and dark bands on a background of gray or a version of brown. 
No known related traits